TBK1 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IKBKE	IKBKG	ENSMMUP00000038190	ENSMMUP00000040739	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.983
IKBKE	IRF3	ENSMMUP00000038190	ENSMMUP00000029942	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	Interferon regulatory factor 3.	0.998
IKBKE	IRF7	ENSMMUP00000038190	ENSMMUP00000009317	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	Interferon regulatory factor 7.	0.964
IKBKE	MAVS	ENSMMUP00000038190	ENSMMUP00000022556	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	Mitochondrial antiviral-signaling protein isoform 1.	0.969
IKBKE	OPTN	ENSMMUP00000038190	ENSMMUP00000065325	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...]	0.861
IKBKE	SQSTM1	ENSMMUP00000038190	ENSMMUP00000033598	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	Sequestosome 1.	0.792
IKBKE	STING1	ENSMMUP00000038190	ENSMMUP00000015803	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	Stimulator of interferon protein.	0.993
IKBKE	TANK	ENSMMUP00000038190	ENSMMUP00000057943	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	TRAF family member-associated NF-kappa-B activator isoform a.	0.997
IKBKE	TBK1	ENSMMUP00000038190	ENSMMUP00000010063	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	Serine/threonine-protein kinase TBK1.	0.998
IKBKE	TRAF3	ENSMMUP00000038190	ENSMMUP00000066374	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.997
IKBKG	IKBKE	ENSMMUP00000040739	ENSMMUP00000038190	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	0.983
IKBKG	IRF3	ENSMMUP00000040739	ENSMMUP00000029942	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Interferon regulatory factor 3.	0.942
IKBKG	IRF7	ENSMMUP00000040739	ENSMMUP00000009317	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Interferon regulatory factor 7.	0.930
IKBKG	MAVS	ENSMMUP00000040739	ENSMMUP00000022556	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Mitochondrial antiviral-signaling protein isoform 1.	0.985
IKBKG	OPTN	ENSMMUP00000040739	ENSMMUP00000065325	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...]	0.416
IKBKG	SQSTM1	ENSMMUP00000040739	ENSMMUP00000033598	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Sequestosome 1.	0.740
IKBKG	TANK	ENSMMUP00000040739	ENSMMUP00000057943	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TRAF family member-associated NF-kappa-B activator isoform a.	0.994
IKBKG	TBK1	ENSMMUP00000040739	ENSMMUP00000010063	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Serine/threonine-protein kinase TBK1.	0.993
IKBKG	TRAF3	ENSMMUP00000040739	ENSMMUP00000066374	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.803
IRF3	IKBKE	ENSMMUP00000029942	ENSMMUP00000038190	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1.	0.998