Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ANKRD13AAnkyrin repeat domain 13A. (788 aa)    
Predicted Functional Partners:
EGFR
Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]
    
 
 0.669
KCNIP2
Uncharacterized protein.
    
   0.595
C12orf43
Chromosome 12 open reading frame 43.
      
 0.544
MMAB
Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.
      
 0.523
GPHA2
Uncharacterized protein.
      
 0.487
PPP2R5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
      
 0.476
TMEM25
Transmembrane protein 25.
      
 0.467
QDPR
Quinoid dihydropteridine reductase.
    
   0.466
LOC709775
Uncharacterized protein.
   
  
 0.435
GLTP
Glycolipid transfer protein.
   
  
 0.435
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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