BACE1 protein (Macaca mulatta) - STRING interaction network

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Score

BACE1

Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa)

Predicted Functional Partners:

APP

0.996

GGA1

0.987

RTN3

0.958

RTN4

0.950

PSEN1

0.914

BACE2

0.907

ADAM10

0.844

GGA3

0.836

PSEN2

0.808

IDE

0.796

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	APP	ENSMMUP00000075812	ENSMMUP00000018894	ADAM metallopeptidase domain 10.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.878
ADAM10	BACE1	ENSMMUP00000075812	ENSMMUP00000010231	ADAM metallopeptidase domain 10.	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	0.844
ADAM10	BACE2	ENSMMUP00000075812	ENSMMUP00000005684	ADAM metallopeptidase domain 10.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.566
ADAM10	IDE	ENSMMUP00000075812	ENSMMUP00000035769	ADAM metallopeptidase domain 10.	Uncharacterized protein; Belongs to the peptidase M16 family.	0.566
ADAM10	PSEN1	ENSMMUP00000075812	ENSMMUP00000032752	ADAM metallopeptidase domain 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.822
ADAM10	PSEN2	ENSMMUP00000075812	ENSMMUP00000075513	ADAM metallopeptidase domain 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.754
APP	ADAM10	ENSMMUP00000018894	ENSMMUP00000075812	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	ADAM metallopeptidase domain 10.	0.878
APP	BACE1	ENSMMUP00000018894	ENSMMUP00000010231	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	0.996
APP	BACE2	ENSMMUP00000018894	ENSMMUP00000005684	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Beta-secretase 2; Belongs to the peptidase A1 family.	0.924
APP	GGA1	ENSMMUP00000018894	ENSMMUP00000037025	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	0.545
APP	GGA3	ENSMMUP00000018894	ENSMMUP00000060578	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Golgi associated, gamma adaptin ear containing, ARF binding protein 3.	0.497
APP	IDE	ENSMMUP00000018894	ENSMMUP00000035769	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Uncharacterized protein; Belongs to the peptidase M16 family.	0.904
APP	PSEN1	ENSMMUP00000018894	ENSMMUP00000032752	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.996
APP	PSEN2	ENSMMUP00000018894	ENSMMUP00000075513	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.978
APP	RTN3	ENSMMUP00000018894	ENSMMUP00000037404	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Reticulon.	0.493
APP	RTN4	ENSMMUP00000018894	ENSMMUP00000028056	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Reticulon.	0.432
BACE1	ADAM10	ENSMMUP00000010231	ENSMMUP00000075812	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	ADAM metallopeptidase domain 10.	0.844
BACE1	APP	ENSMMUP00000010231	ENSMMUP00000018894	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.996
BACE1	BACE2	ENSMMUP00000010231	ENSMMUP00000005684	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.907
BACE1	GGA1	ENSMMUP00000010231	ENSMMUP00000037025	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	0.987