BACE1 protein (Macaca mulatta) - STRING interaction network

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Score

BACE1

Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa)

Predicted Functional Partners:

APP

0.982

RTN4

0.966

RTN3

0.964

GGA1

0.954

BACE2

0.907

PSEN1

0.890

ADAM10

0.785

IDE

0.769

NCSTN

0.760

PSENEN

0.755

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	APP	ENSMMUP00000075812	ENSMMUP00000018894	ADAM metallopeptidase domain 10.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.846
ADAM10	BACE1	ENSMMUP00000075812	ENSMMUP00000010231	ADAM metallopeptidase domain 10.	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	0.785
ADAM10	BACE2	ENSMMUP00000075812	ENSMMUP00000005684	ADAM metallopeptidase domain 10.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.486
ADAM10	IDE	ENSMMUP00000075812	ENSMMUP00000035769	ADAM metallopeptidase domain 10.	Uncharacterized protein; Belongs to the peptidase M16 family.	0.513
ADAM10	NCSTN	ENSMMUP00000075812	ENSMMUP00000038583	ADAM metallopeptidase domain 10.	Nicastrin.	0.849
ADAM10	PSEN1	ENSMMUP00000075812	ENSMMUP00000032752	ADAM metallopeptidase domain 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.785
ADAM10	PSENEN	ENSMMUP00000075812	ENSMMUP00000080461	ADAM metallopeptidase domain 10.	Gamma-secretase subunit PEN-2.	0.754
APP	ADAM10	ENSMMUP00000018894	ENSMMUP00000075812	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	ADAM metallopeptidase domain 10.	0.846
APP	BACE1	ENSMMUP00000018894	ENSMMUP00000010231	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	0.982
APP	BACE2	ENSMMUP00000018894	ENSMMUP00000005684	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Beta-secretase 2; Belongs to the peptidase A1 family.	0.852
APP	GGA1	ENSMMUP00000018894	ENSMMUP00000037025	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	0.427
APP	IDE	ENSMMUP00000018894	ENSMMUP00000035769	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Uncharacterized protein; Belongs to the peptidase M16 family.	0.958
APP	NCSTN	ENSMMUP00000018894	ENSMMUP00000038583	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Nicastrin.	0.963
APP	PSEN1	ENSMMUP00000018894	ENSMMUP00000032752	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.992
APP	PSENEN	ENSMMUP00000018894	ENSMMUP00000080461	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Gamma-secretase subunit PEN-2.	0.866
APP	RTN3	ENSMMUP00000018894	ENSMMUP00000037404	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Reticulon.	0.410
APP	RTN4	ENSMMUP00000018894	ENSMMUP00000028056	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Reticulon.	0.447
BACE1	ADAM10	ENSMMUP00000010231	ENSMMUP00000075812	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	ADAM metallopeptidase domain 10.	0.785
BACE1	APP	ENSMMUP00000010231	ENSMMUP00000018894	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.982
BACE1	BACE2	ENSMMUP00000010231	ENSMMUP00000005684	Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.907