NPPA protein (Macaca mulatta) - STRING interaction network

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Score

NPPA

Natriuretic peptide A. (153 aa)

Predicted Functional Partners:

NPR1

0.997

NPR2

0.996

NPR3

0.994

ADRB1

0.933

CORIN

0.923

GLP1R

0.921

ADRB2

0.913

GIPR

0.906

CRHR1

0.905

CRHR2

0.902

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB1	ADRB2	ENSMMUP00000048016	ENSMMUP00000002958	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	0.974
ADRB1	NPPA	ENSMMUP00000048016	ENSMMUP00000010290	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	Natriuretic peptide A.	0.933
ADRB2	ADRB1	ENSMMUP00000002958	ENSMMUP00000048016	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	0.974
ADRB2	NPPA	ENSMMUP00000002958	ENSMMUP00000010290	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	Natriuretic peptide A.	0.913
CORIN	NPPA	ENSMMUP00000054023	ENSMMUP00000010290	Corin, serine peptidase.	Natriuretic peptide A.	0.923
CRHR1	CRHR2	ENSMMUP00000055825	ENSMMUP00000015437	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...]	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.953
CRHR1	NPPA	ENSMMUP00000055825	ENSMMUP00000010290	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...]	Natriuretic peptide A.	0.905
CRHR2	CRHR1	ENSMMUP00000015437	ENSMMUP00000055825	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...]	0.953
CRHR2	NPPA	ENSMMUP00000015437	ENSMMUP00000010290	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Natriuretic peptide A.	0.902
GIPR	NPPA	ENSMMUP00000009106	ENSMMUP00000010290	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family.	Natriuretic peptide A.	0.906
GLP1R	NPPA	ENSMMUP00000030790	ENSMMUP00000010290	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.	Natriuretic peptide A.	0.921
NPPA	ADRB1	ENSMMUP00000010290	ENSMMUP00000048016	Natriuretic peptide A.	Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).	0.933
NPPA	ADRB2	ENSMMUP00000010290	ENSMMUP00000002958	Natriuretic peptide A.	Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.	0.913
NPPA	CORIN	ENSMMUP00000010290	ENSMMUP00000054023	Natriuretic peptide A.	Corin, serine peptidase.	0.923
NPPA	CRHR1	ENSMMUP00000010290	ENSMMUP00000055825	Natriuretic peptide A.	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...]	0.905
NPPA	CRHR2	ENSMMUP00000010290	ENSMMUP00000015437	Natriuretic peptide A.	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.902
NPPA	GIPR	ENSMMUP00000010290	ENSMMUP00000009106	Natriuretic peptide A.	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family.	0.906
NPPA	GLP1R	ENSMMUP00000010290	ENSMMUP00000030790	Natriuretic peptide A.	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.	0.921
NPPA	NPR1	ENSMMUP00000010290	ENSMMUP00000010672	Natriuretic peptide A.	Guanylate cyclase.	0.997
NPPA	NPR2	ENSMMUP00000010290	ENSMMUP00000021453	Natriuretic peptide A.	Guanylate cyclase.	0.996