STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)    
Predicted Functional Partners:
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
0.994
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.991
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.987
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.
   
0.986
TRAF5
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.978
MAP3K8
Mitogen-activated protein kinase kinase kinase 8.
    
0.972
TRAF6
TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]
   
 0.971
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.965
MAP3K7
Mitogen-activated protein kinase kinase kinase 7.
   
0.929
TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha.
    
 0.914
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.