Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SMC3Structural maintenance of chromosomes protein. (1196 aa)    
Predicted Functional Partners:
SMC1A
Structural maintenance of chromosomes protein.
  
0.999
STAG2
Cohesin subunit SA-2 isoform a.
   
 0.999
RAD21
Double-strand-break repair protein rad21 homolog.
   
 0.999
STAG1
Cohesin subunit SA-1.
   
 0.998
WAPL
WAPL cohesin release factor.
   
 0.997
SMC1B
Structural maintenance of chromosomes protein.
   
0.996
NIPBL
Nipped-B protein.
   
 0.994
ESPL1
Extra spindle pole bodies like 1, separase.
   
 0.992
PDS5A
Sister chromatid cohesion protein PDS5 homolog A isoform 1.
   
 0.992
PDS5B
Sister chromatid cohesion protein PDS5 homolog B.
   
 0.991
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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