| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FCER1G | HCST | ENSMMUP00000006016 | ENSMMUP00000025981 | Fc fragment of IgE receptor Ig. | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | 0.667 |
| FCER1G | KLRD1 | ENSMMUP00000006016 | ENSMMUP00000024061 | Fc fragment of IgE receptor Ig. | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | 0.561 |
| FCER1G | LCK | ENSMMUP00000006016 | ENSMMUP00000044699 | Fc fragment of IgE receptor Ig. | Tyrosine-protein kinase. | 0.485 |
| FCER1G | NCR2 | ENSMMUP00000006016 | ENSMMUP00000004900 | Fc fragment of IgE receptor Ig. | Natural cytotoxicity triggering receptor 2. | 0.501 |
| FCER1G | SYK | ENSMMUP00000006016 | ENSMMUP00000063860 | Fc fragment of IgE receptor Ig. | Tyrosine-protein kinase. | 0.997 |
| FCER1G | TREM2 | ENSMMUP00000006016 | ENSMMUP00000033713 | Fc fragment of IgE receptor Ig. | Triggering receptor expressed on myeloid cells 2. | 0.724 |
| FCER1G | TYROBP | ENSMMUP00000006016 | ENSMMUP00000074812 | Fc fragment of IgE receptor Ig. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.968 |
| FCER1G | ZAP70 | ENSMMUP00000006016 | ENSMMUP00000028374 | Fc fragment of IgE receptor Ig. | Tyrosine-protein kinase. | 0.979 |
| HCST | FCER1G | ENSMMUP00000025981 | ENSMMUP00000006016 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | Fc fragment of IgE receptor Ig. | 0.667 |
| HCST | KLRD1 | ENSMMUP00000025981 | ENSMMUP00000024061 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | 0.753 |
| HCST | NCR2 | ENSMMUP00000025981 | ENSMMUP00000004900 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | Natural cytotoxicity triggering receptor 2. | 0.478 |
| HCST | SYK | ENSMMUP00000025981 | ENSMMUP00000063860 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | Tyrosine-protein kinase. | 0.720 |
| HCST | TYROBP | ENSMMUP00000025981 | ENSMMUP00000074812 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.963 |
| HCST | ZAP70 | ENSMMUP00000025981 | ENSMMUP00000028374 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | Tyrosine-protein kinase. | 0.603 |
| KLRD1 | FCER1G | ENSMMUP00000024061 | ENSMMUP00000006016 | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | Fc fragment of IgE receptor Ig. | 0.561 |
| KLRD1 | HCST | ENSMMUP00000024061 | ENSMMUP00000025981 | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] | 0.753 |
| KLRD1 | LCK | ENSMMUP00000024061 | ENSMMUP00000044699 | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | Tyrosine-protein kinase. | 0.542 |
| KLRD1 | NCR2 | ENSMMUP00000024061 | ENSMMUP00000004900 | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | Natural cytotoxicity triggering receptor 2. | 0.443 |
| KLRD1 | SYK | ENSMMUP00000024061 | ENSMMUP00000063860 | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | Tyrosine-protein kinase. | 0.564 |
| KLRD1 | TYROBP | ENSMMUP00000024061 | ENSMMUP00000074812 | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.994 |
STRING v12.5 is now available!
