Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)    
Predicted Functional Partners:
LMNA
Prelamin-A/C isoform 1; Belongs to the intermediate filament family.
   
 0.991
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
0.987
LMNB1
Lamin-B1 isoform 1; Belongs to the intermediate filament family.
   
 0.977
LMNB2
Lamin B2; Belongs to the intermediate filament family.
   
 0.977
CASP9
Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family.
    
0.973
ACTG1
Actin, cytoplasmic 2.
    
 0.914
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.825
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 
 0.819
CASP10
Caspase 10; Belongs to the peptidase C14A family.
   
0.798
SATB1
DNA-binding protein SATB.
    
 0.780
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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