node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL5 | CXCL1 | ENSMMUP00000073204 | ENSMMUP00000010972 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine. | 0.974 |
CCL5 | CXCL10 | ENSMMUP00000073204 | ENSMMUP00000027500 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.994 |
CCL5 | CXCL12 | ENSMMUP00000073204 | ENSMMUP00000035953 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | 0.987 |
CCL5 | CXCL3 | ENSMMUP00000073204 | ENSMMUP00000076400 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine. | 0.938 |
CCL5 | CXCR1 | ENSMMUP00000073204 | ENSMMUP00000065767 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity (By similarity). | 0.918 |
CCL5 | CXCR2 | ENSMMUP00000073204 | ENSMMUP00000067534 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). | 0.955 |
CCL5 | JUN | ENSMMUP00000073204 | ENSMMUP00000074392 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Transcription factor AP-1; Belongs to the bZIP family. | 0.930 |
CCL5 | LOC703390 | ENSMMUP00000073204 | ENSMMUP00000068066 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine. | 0.794 |
CCL5 | NFKB1 | ENSMMUP00000073204 | ENSMMUP00000034946 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Uncharacterized protein. | 0.943 |
CCL5 | RELA | ENSMMUP00000073204 | ENSMMUP00000054901 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | RELA proto-oncogene, NF-kB subunit. | 0.923 |
CXCL1 | CCL5 | ENSMMUP00000010972 | ENSMMUP00000073204 | C-X-C motif chemokine. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.974 |
CXCL1 | CXCL10 | ENSMMUP00000010972 | ENSMMUP00000027500 | C-X-C motif chemokine. | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.973 |
CXCL1 | CXCL12 | ENSMMUP00000010972 | ENSMMUP00000035953 | C-X-C motif chemokine. | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. | 0.947 |
CXCL1 | CXCL3 | ENSMMUP00000010972 | ENSMMUP00000076400 | C-X-C motif chemokine. | C-X-C motif chemokine. | 0.968 |
CXCL1 | CXCR1 | ENSMMUP00000010972 | ENSMMUP00000065767 | C-X-C motif chemokine. | C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity (By similarity). | 0.980 |
CXCL1 | CXCR2 | ENSMMUP00000010972 | ENSMMUP00000067534 | C-X-C motif chemokine. | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). | 0.996 |
CXCL1 | JUN | ENSMMUP00000010972 | ENSMMUP00000074392 | C-X-C motif chemokine. | Transcription factor AP-1; Belongs to the bZIP family. | 0.917 |
CXCL1 | LOC703390 | ENSMMUP00000010972 | ENSMMUP00000068066 | C-X-C motif chemokine. | C-X-C motif chemokine. | 0.967 |
CXCL1 | NFKB1 | ENSMMUP00000010972 | ENSMMUP00000034946 | C-X-C motif chemokine. | Uncharacterized protein. | 0.909 |
CXCL1 | RELA | ENSMMUP00000010972 | ENSMMUP00000054901 | C-X-C motif chemokine. | RELA proto-oncogene, NF-kB subunit. | 0.916 |