PTEN protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSNK2A1	PTEN	ENSMMUP00000037657	ENSMMUP00000011055	Casein kinase II subunit alpha isoform a; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.971
CSNK2A1	TP53	ENSMMUP00000037657	ENSMMUP00000011334	Casein kinase II subunit alpha isoform a; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.873
DLG1	PTEN	ENSMMUP00000038226	ENSMMUP00000011055	Disks large homolog 1 isoform 2; Belongs to the MAGUK family.	Uncharacterized protein.	0.973
MAGI2	PTEN	ENSMMUP00000051916	ENSMMUP00000011055	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	Uncharacterized protein.	0.983
PIK3C3	PIK3CA	ENSMMUP00000046296	ENSMMUP00000006866	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.854
PIK3C3	PIK3CB	ENSMMUP00000046296	ENSMMUP00000011365	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.852
PIK3C3	PIK3CD	ENSMMUP00000046296	ENSMMUP00000068489	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.772
PIK3C3	PIK3R1	ENSMMUP00000046296	ENSMMUP00000015140	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphoinositide-3-kinase regulatory subunit 1.	0.980
PIK3C3	PTEN	ENSMMUP00000046296	ENSMMUP00000011055	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Uncharacterized protein.	0.986
PIK3C3	TP53	ENSMMUP00000046296	ENSMMUP00000011334	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.621
PIK3CA	PIK3C3	ENSMMUP00000006866	ENSMMUP00000046296	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.854
PIK3CA	PIK3CB	ENSMMUP00000006866	ENSMMUP00000011365	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.988
PIK3CA	PIK3CD	ENSMMUP00000006866	ENSMMUP00000068489	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.984
PIK3CA	PIK3R1	ENSMMUP00000006866	ENSMMUP00000015140	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphoinositide-3-kinase regulatory subunit 1.	0.999
PIK3CA	PTEN	ENSMMUP00000006866	ENSMMUP00000011055	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Uncharacterized protein.	0.991
PIK3CA	PTK2	ENSMMUP00000006866	ENSMMUP00000049969	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.984
PIK3CA	TP53	ENSMMUP00000006866	ENSMMUP00000011334	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.886
PIK3CB	PIK3C3	ENSMMUP00000011365	ENSMMUP00000046296	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.852
PIK3CB	PIK3CA	ENSMMUP00000011365	ENSMMUP00000006866	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.988
PIK3CB	PIK3CD	ENSMMUP00000011365	ENSMMUP00000068489	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.974