STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (433 aa)    
Predicted Functional Partners:
AGT
Angiotensinogen preproprotein; Belongs to the serpin family.
   
 0.993
ATP6AP2
Renin/prorenin receptor.
   
 0.992
ACE
Angiotensin-converting enzyme.
      
 0.953
ACE2
Angiotensin-converting enzyme.
      
 0.928
AGTR1
Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.
      
 0.803
NR3C2
Nuclear receptor subfamily 3 group C member 2.
    
 
 0.789
TMPRSS2
Transmembrane serine protease 2; Belongs to the peptidase S1 family.
   
 
 0.785
EDN1
Preproendothelin-1.
   
  
 0.741
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 0.739
AGTR2
Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.729
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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