Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PHF8Histone lysine demethylase PHF8 isoform 1. (1060 aa)    
Predicted Functional Partners:
H3-4
Histone H3; Belongs to the histone H3 family.
    
 0.810
TOPBP1
Uncharacterized protein.
    
 
 0.738
ZNF711
Uncharacterized protein.
   
 0.738
CCNA2
Cyclin-A2; Belongs to the cyclin family.
    
 0.716
POLR2A
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.687
ARID5B
AT-rich interaction domain 5B.
    
 0.671
NCAPG2
Uncharacterized protein.
   
 
 0.666
LOC114669830
Histone H3; Belongs to the histone H3 family.
    
 0.665
NCAPD3
Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
   
 
 0.663
SETD7
Uncharacterized protein.
    
 0.655
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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