Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPP1Secreted phosphoprotein 1. (314 aa)    
Predicted Functional Partners:
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
    
 0.982
ITGA9
Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.
   
 0.975
ITGAV
Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.
   
 0.974
ITGB3
Integrin beta; Belongs to the integrin beta chain family.
    
 0.973
CD44
Phagocytic glycoprotein I.
   
 0.971
ITGA4
Integrin subunit alpha 4; Belongs to the integrin alpha chain family.
   
 0.960
ITGB5
Integrin beta; Belongs to the integrin beta chain family.
   
 0.960
IRF7
Interferon regulatory factor 7.
    
 0.914
MMP7
Matrix metallopeptidase 7.
   
 0.909
CGA
Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
   
 
 0.903
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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