| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOBEC3B | LTB | ENSMMUP00000014096 | ENSMMUP00000011600 | Uncharacterized protein. | Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity). | 0.630 |
| CCR7 | CD40 | ENSMMUP00000002799 | ENSMMUP00000004910 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Tumor necrosis factor receptor superfamily member 5 isoform 1. | 0.820 |
| CCR7 | CD40LG | ENSMMUP00000002799 | ENSMMUP00000040794 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | 0.767 |
| CCR7 | LTA | ENSMMUP00000002799 | ENSMMUP00000011590 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. | 0.603 |
| CCR7 | LTB | ENSMMUP00000002799 | ENSMMUP00000011600 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity). | 0.564 |
| CD40 | CCR7 | ENSMMUP00000004910 | ENSMMUP00000002799 | Tumor necrosis factor receptor superfamily member 5 isoform 1. | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.820 |
| CD40 | CD40LG | ENSMMUP00000004910 | ENSMMUP00000040794 | Tumor necrosis factor receptor superfamily member 5 isoform 1. | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | 0.999 |
| CD40 | LTA | ENSMMUP00000004910 | ENSMMUP00000011590 | Tumor necrosis factor receptor superfamily member 5 isoform 1. | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. | 0.681 |
| CD40 | LTB | ENSMMUP00000004910 | ENSMMUP00000011600 | Tumor necrosis factor receptor superfamily member 5 isoform 1. | Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity). | 0.619 |
| CD40 | RELB | ENSMMUP00000004910 | ENSMMUP00000018596 | Tumor necrosis factor receptor superfamily member 5 isoform 1. | RELB proto-oncogene, NF-kB subunit. | 0.473 |
| CD40 | TNFSF13B | ENSMMUP00000004910 | ENSMMUP00000036043 | Tumor necrosis factor receptor superfamily member 5 isoform 1. | TNF-and APOL-related leukocyte expressed ligand 1; Belongs to the tumor necrosis factor family. | 0.672 |
| CD40 | TNFSF14 | ENSMMUP00000004910 | ENSMMUP00000078223 | Tumor necrosis factor receptor superfamily member 5 isoform 1. | TNF superfamily member 14; Belongs to the tumor necrosis factor family. | 0.652 |
| CD40LG | CCR7 | ENSMMUP00000040794 | ENSMMUP00000002799 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.767 |
| CD40LG | CD40 | ENSMMUP00000040794 | ENSMMUP00000004910 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Tumor necrosis factor receptor superfamily member 5 isoform 1. | 0.999 |
| CD40LG | LTA | ENSMMUP00000040794 | ENSMMUP00000011590 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. | 0.769 |
| CD40LG | LTB | ENSMMUP00000040794 | ENSMMUP00000011600 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity). | 0.624 |
| CD40LG | LTBR | ENSMMUP00000040794 | ENSMMUP00000049866 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Uncharacterized protein. | 0.766 |
| CD40LG | RELB | ENSMMUP00000040794 | ENSMMUP00000018596 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | RELB proto-oncogene, NF-kB subunit. | 0.450 |
| CD40LG | TNFRSF14 | ENSMMUP00000040794 | ENSMMUP00000040667 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | TNF receptor superfamily member 14. | 0.648 |
| CD40LG | TNFSF13B | ENSMMUP00000040794 | ENSMMUP00000036043 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | TNF-and APOL-related leukocyte expressed ligand 1; Belongs to the tumor necrosis factor family. | 0.779 |