STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THAP6THAP domain containing 6. (282 aa)    
Predicted Functional Partners:
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
   
 0.635
CNBD2
Cyclic nucleotide binding domain containing 2.
   
 0.635
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
   
 0.635
PRKAR1B
Cyclic nucleotide-binding domain-containing protein.
   
 0.635
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
   
 0.635
PRKG1
cGMP-dependent protein kinase.
   
 0.583
PRKG2
cGMP-dependent protein kinase.
   
 0.582
PNPLA7
Patatin like phospholipase domain containing 7.
   
 0.557
PNPLA6
Patatin like phospholipase domain containing 6.
   
 0.557
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 0.554
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.