Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)    
Predicted Functional Partners:
HSPA5
78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.
   
 0.999
EIF2S1
Eukaryotic translation initiation factor 2 subunit alpha.
   
 0.995
NFE2L2
Nuclear factor erythroid 2-related factor 2 isoform 1.
   
 0.974
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1.
   
0.952
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
0.952
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.938
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 
 0.918
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
     
 0.908
IFIT1
Interferon-induced protein with tetratricopeptide repeats 1 isoform 2.
   
  0.906
DNAJC3
Interferon-induced, double-stranded RNA-activated protein kinase inhibitor.
   
 0.891
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.