Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PDLIM4PDZ and LIM domain protein 4 isoform 1. (330 aa)    
Predicted Functional Partners:
PDLIM2
Uncharacterized protein.
     
0.934
DPYSL3
Dihydropyrimidinase like 3.
     
 0.921
LDB3
LIM domain binding 3.
   
 
0.908
SPECC1
Sperm antigen with calponin homology and coiled-coil domains 1.
   
  0.902
PDLIM1
PDZ and LIM domain 1.
     
 
0.900
TMSB15A
Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.
     
  0.900
CNN3
Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
   
 
 0.789
RSPH1
Radial spoke head component 1.
   
  
 0.788
NCKAP1
Nck-associated protein 1 isoform 2.
   
 
 0.741
PTPN13
Protein tyrosine phosphatase non-receptor type 13.
    
 0.688
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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