Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (543 aa)    
Predicted Functional Partners:
ITGAL
Integrin subunit alpha L; Belongs to the integrin alpha chain family.
   
 0.997
ITGB2
Integrin beta.
   
 0.995
ITGAM
Integrin subunit alpha M; Belongs to the integrin alpha chain family.
   
 0.990
RELA
RELA proto-oncogene, NF-kB subunit.
   
 0.982
NFKB1
Uncharacterized protein.
   
 0.979
VCAM1
Vascular cell adhesion molecule 1.
   
 
 0.955
EZR
Ezrin.
    
 0.944
MSN
FERM domain-containing protein.
    
 0.938
ICAM2
ICAM_N domain-containing protein.
  
  
0.924
SELE
Selectin E.
   
 
 0.918
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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