Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SHANK1SH3 and multiple ankyrin repeat domains 1. (2163 aa)    
Predicted Functional Partners:
SHANK3
SH3 and multiple ankyrin repeat domains 3.
  
 
0.982
DLGAP1
Disks large-associated protein 1 isoform 1.
   
 0.970
HOMER1
Homer scaffold protein 1.
    
 0.964
SHANK2
SH3 and multiple ankyrin repeat domains 2.
   
0.946
DLGAP3
Disks large-associated protein 3.
   
 0.945
DLG4
Uncharacterized protein; Belongs to the MAGUK family.
   
 0.926
LZTS3
Leucine zipper tumor suppressor family member 3.
    
 0.913
DLGAP2
DLG associated protein 2.
   
 0.912
SHARPIN
Sharpin.
    
 0.892
HOMER3
WH1 domain-containing protein.
    
 0.815
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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