TNS4 protein (Macaca mulatta) - STRING interaction network

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[Homology]

Score

TNS4

Tensin 4. (716 aa)

Predicted Functional Partners:

ITGB1

0.946

ITGB7

0.639

ITGB2

0.639

KIF3B

0.612

CBL

0.538

HGF

0.530

MST1

0.530

VGF

0.529

EGFR

0.503

ITGB3

0.490

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	EGFR	ENSMMUP00000059041	ENSMMUP00000046120	E3 ubiquitin-protein ligase CBL.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.999
CBL	HGF	ENSMMUP00000059041	ENSMMUP00000024541	E3 ubiquitin-protein ligase CBL.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.729
CBL	MST1	ENSMMUP00000059041	ENSMMUP00000069589	E3 ubiquitin-protein ligase CBL.	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.562
CBL	TNS4	ENSMMUP00000059041	ENSMMUP00000012289	E3 ubiquitin-protein ligase CBL.	Tensin 4.	0.538
EGFR	CBL	ENSMMUP00000046120	ENSMMUP00000059041	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	E3 ubiquitin-protein ligase CBL.	0.999
EGFR	HGF	ENSMMUP00000046120	ENSMMUP00000024541	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.848
EGFR	ITGB1	ENSMMUP00000046120	ENSMMUP00000023374	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Integrin beta; Belongs to the integrin beta chain family.	0.781
EGFR	ITGB2	ENSMMUP00000046120	ENSMMUP00000073991	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Integrin beta.	0.734
EGFR	ITGB3	ENSMMUP00000046120	ENSMMUP00000004380	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Integrin beta; Belongs to the integrin beta chain family.	0.429
EGFR	MST1	ENSMMUP00000046120	ENSMMUP00000069589	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.691
EGFR	TNS4	ENSMMUP00000046120	ENSMMUP00000012289	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tensin 4.	0.503
HGF	CBL	ENSMMUP00000024541	ENSMMUP00000059041	Hepatocyte growth factor; Belongs to the peptidase S1 family.	E3 ubiquitin-protein ligase CBL.	0.729
HGF	EGFR	ENSMMUP00000024541	ENSMMUP00000046120	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.848
HGF	ITGB1	ENSMMUP00000024541	ENSMMUP00000023374	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Integrin beta; Belongs to the integrin beta chain family.	0.713
HGF	TNS4	ENSMMUP00000024541	ENSMMUP00000012289	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Tensin 4.	0.530
ITGB1	EGFR	ENSMMUP00000023374	ENSMMUP00000046120	Integrin beta; Belongs to the integrin beta chain family.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.781
ITGB1	HGF	ENSMMUP00000023374	ENSMMUP00000024541	Integrin beta; Belongs to the integrin beta chain family.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.713
ITGB1	ITGB2	ENSMMUP00000023374	ENSMMUP00000073991	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta.	0.916
ITGB1	ITGB3	ENSMMUP00000023374	ENSMMUP00000004380	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.655
ITGB1	ITGB7	ENSMMUP00000023374	ENSMMUP00000006941	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.402