Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FBXL5F-box and leucine rich repeat protein 5. (765 aa)    
Predicted Functional Partners:
IREB2
Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family.
    
 0.991
CUL1
Cullin 1; Belongs to the cullin family.
    
 0.989
SKP1-2
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.988
MMS19
MMS19 homolog, cytosolic iron-sulfur assembly component.
    
 
 0.949
ACO1
Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family.
    
 0.936
CIAO2B
Cytosolic iron-sulfur assembly component 2B.
    
 
 0.904
CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family.
    
 
 0.808
COPS5
COP9 signalosome complex subunit 5.
    
 0.735
RBX1
E3 ubiquitin-protein ligase RBX1.
    
 0.730
CUL3
Cullin-3; Belongs to the cullin family.
    
 0.715
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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