Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CES1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (611 aa)    
Predicted Functional Partners:
CES2
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
  
 
0.951
GUSBA
Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.
    
 0.927
UGT2B7
UDP-glucuronosyltransferase 2B33; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid.
   
 
 0.918
MPO
Myeloperoxidase.
    
 0.916
UGT2A3
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 
 0.912
LOC709234
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 
 0.909
UGT2A1
UDP glucuronosyltransferase family 2 member A1 complex locus; Belongs to the UDP-glycosyltransferase family.
   
 
 0.909
LOC709132
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 
 0.909
UGT1A1
UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.
     
 0.909
CYP2E1
Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
   
 0.909
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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