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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H2AFB3Histone H2A; Belongs to the histone H2A family. (115 aa)    
Predicted Functional Partners:
RNF2
E3 ubiquitin-protein ligase RING2.
    
 0.808
H2BC5
Histone H2B; Belongs to the histone H2B family.
   
 0.808
HDAC2
Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
    
 0.801
H2BC18
Histone H2B; Belongs to the histone H2B family.
   
 0.799
LOC114669830
Histone H3; Belongs to the histone H3 family.
   
 0.793
HIST1H2BO
Histone H2B; Belongs to the histone H2B family.
   
 0.785
H3-4
Histone H3; Belongs to the histone H3 family.
   
 0.782
H2AC20
Histone H2A; Belongs to the histone H2A family.
   
  0.778
HIST1H2AC
Histone H2A; Belongs to the histone H2A family.
   
  0.778
H2AFJ
Histone H2A; Belongs to the histone H2A family.
   
  0.777
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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