MKRN2 protein (Macaca mulatta) - STRING interaction network

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MKRN2

Putative E3 ubiquitin-protein ligase makorin-2. (416 aa)

Predicted Functional Partners:

HAGH

0.799

PAIP1

0.799

EIF4G1

0.730

IGF2BP3

0.726

ZC3HAV1

0.715

ATG7

0.660

ZNF598

0.658

PABPC3

0.656

PABPC4

0.633

PDLIM2

0.627

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG7	MKRN2	ENSMMUP00000028719	ENSMMUP00000012473	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Putative E3 ubiquitin-protein ligase makorin-2.	0.660
EIF4G1	MKRN2	ENSMMUP00000014338	ENSMMUP00000012473	Eukaryotic translation initiation factor 4 gamma 1 isoform 6.	Putative E3 ubiquitin-protein ligase makorin-2.	0.730
EIF4G1	PABPC3	ENSMMUP00000014338	ENSMMUP00000027420	Eukaryotic translation initiation factor 4 gamma 1 isoform 6.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.889
EIF4G1	PABPC4	ENSMMUP00000014338	ENSMMUP00000065215	Eukaryotic translation initiation factor 4 gamma 1 isoform 6.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.802
EIF4G1	PAIP1	ENSMMUP00000014338	ENSMMUP00000015596	Eukaryotic translation initiation factor 4 gamma 1 isoform 6.	Polyadenylate-binding protein-interacting protein 1 isoform 1.	0.677
HAGH	MKRN2	ENSMMUP00000000990	ENSMMUP00000012473	Hydroxyacylglutathione hydrolase.	Putative E3 ubiquitin-protein ligase makorin-2.	0.799
IGF2BP3	MKRN2	ENSMMUP00000035154	ENSMMUP00000012473	Insulin like growth factor 2 mRNA binding protein 3.	Putative E3 ubiquitin-protein ligase makorin-2.	0.726
IGF2BP3	PABPC4	ENSMMUP00000035154	ENSMMUP00000065215	Insulin like growth factor 2 mRNA binding protein 3.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.440
IGF2BP3	PAIP1	ENSMMUP00000035154	ENSMMUP00000015596	Insulin like growth factor 2 mRNA binding protein 3.	Polyadenylate-binding protein-interacting protein 1 isoform 1.	0.494
MKRN2	ATG7	ENSMMUP00000012473	ENSMMUP00000028719	Putative E3 ubiquitin-protein ligase makorin-2.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.660
MKRN2	EIF4G1	ENSMMUP00000012473	ENSMMUP00000014338	Putative E3 ubiquitin-protein ligase makorin-2.	Eukaryotic translation initiation factor 4 gamma 1 isoform 6.	0.730
MKRN2	HAGH	ENSMMUP00000012473	ENSMMUP00000000990	Putative E3 ubiquitin-protein ligase makorin-2.	Hydroxyacylglutathione hydrolase.	0.799
MKRN2	IGF2BP3	ENSMMUP00000012473	ENSMMUP00000035154	Putative E3 ubiquitin-protein ligase makorin-2.	Insulin like growth factor 2 mRNA binding protein 3.	0.726
MKRN2	PABPC3	ENSMMUP00000012473	ENSMMUP00000027420	Putative E3 ubiquitin-protein ligase makorin-2.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.656
MKRN2	PABPC4	ENSMMUP00000012473	ENSMMUP00000065215	Putative E3 ubiquitin-protein ligase makorin-2.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.633
MKRN2	PAIP1	ENSMMUP00000012473	ENSMMUP00000015596	Putative E3 ubiquitin-protein ligase makorin-2.	Polyadenylate-binding protein-interacting protein 1 isoform 1.	0.799
MKRN2	PDLIM2	ENSMMUP00000012473	ENSMMUP00000024368	Putative E3 ubiquitin-protein ligase makorin-2.	Uncharacterized protein.	0.627
MKRN2	ZC3HAV1	ENSMMUP00000012473	ENSMMUP00000008624	Putative E3 ubiquitin-protein ligase makorin-2.	Zinc finger CCCH-type containing, antiviral 1.	0.715
MKRN2	ZNF598	ENSMMUP00000012473	ENSMMUP00000026320	Putative E3 ubiquitin-protein ligase makorin-2.	Zinc finger protein 598.	0.658
PABPC3	EIF4G1	ENSMMUP00000027420	ENSMMUP00000014338	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	Eukaryotic translation initiation factor 4 gamma 1 isoform 6.	0.889