BCR protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

BCR

BCR activator of RhoGEF and GTPase. (1271 aa)

Predicted Functional Partners:

ABL1

0.997

GRB2

0.995

CBL

0.978

CRK

0.955

STAT5A

0.949

STAT5B

0.941

SHC1

0.910

SHC3

0.908

SHC4

0.904

SHC2

0.904

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCR	ENSMMUP00000053665	ENSMMUP00000012482	Tyrosine-protein kinase.	BCR activator of RhoGEF and GTPase.	0.997
ABL1	CBL	ENSMMUP00000053665	ENSMMUP00000059041	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL.	0.992
ABL1	CRK	ENSMMUP00000053665	ENSMMUP00000042452	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.994
ABL1	GRB2	ENSMMUP00000053665	ENSMMUP00000045339	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2 isoform 1.	0.991
ABL1	SHC1	ENSMMUP00000053665	ENSMMUP00000008658	Tyrosine-protein kinase.	SHC-transforming protein 1 isoform 3.	0.991
ABL1	SHC2	ENSMMUP00000053665	ENSMMUP00000072267	Tyrosine-protein kinase.	Uncharacterized protein.	0.928
ABL1	SHC3	ENSMMUP00000053665	ENSMMUP00000049326	Tyrosine-protein kinase.	Uncharacterized protein.	0.969
ABL1	SHC4	ENSMMUP00000053665	ENSMMUP00000054675	Tyrosine-protein kinase.	Src-like proteiny 2 domain-containing-transforming protein C4.	0.928
ABL1	STAT5A	ENSMMUP00000053665	ENSMMUP00000050038	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.959
ABL1	STAT5B	ENSMMUP00000053665	ENSMMUP00000004582	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.959
BCR	ABL1	ENSMMUP00000012482	ENSMMUP00000053665	BCR activator of RhoGEF and GTPase.	Tyrosine-protein kinase.	0.997
BCR	CBL	ENSMMUP00000012482	ENSMMUP00000059041	BCR activator of RhoGEF and GTPase.	E3 ubiquitin-protein ligase CBL.	0.978
BCR	CRK	ENSMMUP00000012482	ENSMMUP00000042452	BCR activator of RhoGEF and GTPase.	CRK proto-oncogene, adaptor protein.	0.955
BCR	GRB2	ENSMMUP00000012482	ENSMMUP00000045339	BCR activator of RhoGEF and GTPase.	Growth factor receptor-bound protein 2 isoform 1.	0.995
BCR	SHC1	ENSMMUP00000012482	ENSMMUP00000008658	BCR activator of RhoGEF and GTPase.	SHC-transforming protein 1 isoform 3.	0.910
BCR	SHC2	ENSMMUP00000012482	ENSMMUP00000072267	BCR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.904
BCR	SHC3	ENSMMUP00000012482	ENSMMUP00000049326	BCR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.908
BCR	SHC4	ENSMMUP00000012482	ENSMMUP00000054675	BCR activator of RhoGEF and GTPase.	Src-like proteiny 2 domain-containing-transforming protein C4.	0.904
BCR	STAT5A	ENSMMUP00000012482	ENSMMUP00000050038	BCR activator of RhoGEF and GTPase.	Signal transducer and activator of transcription.	0.949
BCR	STAT5B	ENSMMUP00000012482	ENSMMUP00000004582	BCR activator of RhoGEF and GTPase.	Signal transducer and activator of transcription.	0.941