Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)    
Predicted Functional Partners:
CDK5
Cyclin dependent kinase 5.
    
 0.999
MAPT
Microtubule-associated protein.
   
 0.946
CAPN1
Calpain-1 catalytic subunit; Belongs to the peptidase C2 family.
   
 0.943
CAPN2
Calpain-2 catalytic subunit isoform 1; Belongs to the peptidase C2 family.
   
 0.939
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.809
VSNL1
Visinin like 1.
   
  
 0.752
ATN1
Atrophin 1.
      
 0.640
PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial.
      
 0.627
LRCH1
Leucine rich repeats and calponin homology domain containing 1.
      
 0.610
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
      
 0.596
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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