PTPN18 protein (Macaca mulatta) - STRING interaction network

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Score

PTPN18

Protein tyrosine phosphatase non-receptor type 18. (456 aa)

Predicted Functional Partners:

EGFR

0.822

PSTPIP1

0.817

LRRC49

0.715

CSK

0.704

MATK

0.704

CCDC77

0.703

ERBB2

0.698

IQCA1

0.673

FRMPD2

0.667

THAP10

0.666

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC77	IQCA1	ENSMMUP00000063553	ENSMMUP00000022914	Coiled-coil domain containing 77.	IQ motif containing with AAA domain 1.	0.753
CCDC77	LRRC49	ENSMMUP00000063553	ENSMMUP00000019770	Coiled-coil domain containing 77.	Leucine-rich repeat-containing protein 49 isoform 2.	0.773
CCDC77	PTPN18	ENSMMUP00000063553	ENSMMUP00000012588	Coiled-coil domain containing 77.	Protein tyrosine phosphatase non-receptor type 18.	0.703
CCDC77	THAP10	ENSMMUP00000063553	ENSMMUP00000019768	Coiled-coil domain containing 77.	THAP domain containing 10.	0.767
CSK	EGFR	ENSMMUP00000071007	ENSMMUP00000046120	Tyrosine-protein kinase.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.949
CSK	ERBB2	ENSMMUP00000071007	ENSMMUP00000064366	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.654
CSK	MATK	ENSMMUP00000071007	ENSMMUP00000079139	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.502
CSK	PTPN18	ENSMMUP00000071007	ENSMMUP00000012588	Tyrosine-protein kinase.	Protein tyrosine phosphatase non-receptor type 18.	0.704
EGFR	CSK	ENSMMUP00000046120	ENSMMUP00000071007	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase.	0.949
EGFR	ERBB2	ENSMMUP00000046120	ENSMMUP00000064366	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Receptor protein-tyrosine kinase.	0.996
EGFR	MATK	ENSMMUP00000046120	ENSMMUP00000079139	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase.	0.818
EGFR	PTPN18	ENSMMUP00000046120	ENSMMUP00000012588	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Protein tyrosine phosphatase non-receptor type 18.	0.822
ERBB2	CSK	ENSMMUP00000064366	ENSMMUP00000071007	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.654
ERBB2	EGFR	ENSMMUP00000064366	ENSMMUP00000046120	Receptor protein-tyrosine kinase.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.996
ERBB2	MATK	ENSMMUP00000064366	ENSMMUP00000079139	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.807
ERBB2	PTPN18	ENSMMUP00000064366	ENSMMUP00000012588	Receptor protein-tyrosine kinase.	Protein tyrosine phosphatase non-receptor type 18.	0.698
FRMPD2	PTPN18	ENSMMUP00000005426	ENSMMUP00000012588	FERM and PDZ domain containing 2.	Protein tyrosine phosphatase non-receptor type 18.	0.667
IQCA1	CCDC77	ENSMMUP00000022914	ENSMMUP00000063553	IQ motif containing with AAA domain 1.	Coiled-coil domain containing 77.	0.753
IQCA1	LRRC49	ENSMMUP00000022914	ENSMMUP00000019770	IQ motif containing with AAA domain 1.	Leucine-rich repeat-containing protein 49 isoform 2.	0.778
IQCA1	PTPN18	ENSMMUP00000022914	ENSMMUP00000012588	IQ motif containing with AAA domain 1.	Protein tyrosine phosphatase non-receptor type 18.	0.673