Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DHX15Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (795 aa)    
Predicted Functional Partners:
RBM17
45 kDa-splicing factor.
   
 0.996
TFIP11
Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...]
   
 0.995
SF3B1
SF3b1 domain-containing protein.
   
 0.991
PHF5A
PHD finger-like domain-containing protein 5A.
   
 0.988
SF3B3
Spliceosome-associated protein 130.
   
 0.986
SNRPA1
LRRcap domain-containing protein.
   
 0.984
U2SURP
U2 snRNP associated SURP domain containing.
   
 0.978
SF3A2
Splicing factor 3a subunit 2.
    
 0.978
CHERP
Calcium homeostasis endoplasmic reticulum protein.
   
 0.974
SF3A1
Splicing factor 3A subunit 1 isoform 1.
   
 0.970
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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