Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PRRT2Proline-rich transmembrane protein 2 isoform 1. (340 aa)    
Predicted Functional Partners:
ARNTL
Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a.
    
 0.782
C2CD2L
C2 domain-containing protein 2-like.
    
 
 0.776
SCN2A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
   
 
 0.740
PRRT3
Proline-rich transmembrane protein 3.
   
  
 0.739
NDUFV3
NADH:ubiquinone oxidoreductase subunit V3.
    
   0.735
NDUFB9
NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family.
    
  0.729
NDUFS4
NADH:ubiquinone oxidoreductase subunit S4.
    
   0.723
DIRAS2
Distinct subgroup of the Ras family member 2.
   
 0.711
INPP4A
Uncharacterized protein.
      
 0.701
SCN1A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
   
 
 0.697
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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