| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGRP | CCK | ENSMMUP00000071178 | ENSMMUP00000001437 | Agouti related neuropeptide. | Cholecystokinin preproprotein. | 0.851 |
| AGRP | LEP | ENSMMUP00000071178 | ENSMMUP00000007035 | Agouti related neuropeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.946 |
| AGRP | NPY | ENSMMUP00000071178 | ENSMMUP00000070707 | Agouti related neuropeptide. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. | 0.955 |
| AGRP | NPY1R | ENSMMUP00000071178 | ENSMMUP00000080517 | Agouti related neuropeptide. | Neuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. | 0.444 |
| AGRP | NPY2R | ENSMMUP00000071178 | ENSMMUP00000018630 | Agouti related neuropeptide. | Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. | 0.526 |
| AGRP | NPY5R | ENSMMUP00000071178 | ENSMMUP00000026648 | Agouti related neuropeptide. | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.493 |
| AGRP | POMC | ENSMMUP00000071178 | ENSMMUP00000075833 | Agouti related neuropeptide. | Uncharacterized protein. | 0.967 |
| AGRP | PPY | ENSMMUP00000071178 | ENSMMUP00000074126 | Agouti related neuropeptide. | Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. | 0.562 |
| AGRP | SST | ENSMMUP00000071178 | ENSMMUP00000001145 | Agouti related neuropeptide. | Somatostatin preproprotein. | 0.510 |
| CCK | AGRP | ENSMMUP00000001437 | ENSMMUP00000071178 | Cholecystokinin preproprotein. | Agouti related neuropeptide. | 0.851 |
| CCK | LEP | ENSMMUP00000001437 | ENSMMUP00000007035 | Cholecystokinin preproprotein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.869 |
| CCK | NPY | ENSMMUP00000001437 | ENSMMUP00000070707 | Cholecystokinin preproprotein. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. | 0.947 |
| CCK | NPY2R | ENSMMUP00000001437 | ENSMMUP00000018630 | Cholecystokinin preproprotein. | Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. | 0.593 |
| CCK | POMC | ENSMMUP00000001437 | ENSMMUP00000075833 | Cholecystokinin preproprotein. | Uncharacterized protein. | 0.760 |
| CCK | PPY | ENSMMUP00000001437 | ENSMMUP00000074126 | Cholecystokinin preproprotein. | Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. | 0.688 |
| CCK | SST | ENSMMUP00000001437 | ENSMMUP00000001145 | Cholecystokinin preproprotein. | Somatostatin preproprotein. | 0.947 |
| LEP | AGRP | ENSMMUP00000007035 | ENSMMUP00000071178 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Agouti related neuropeptide. | 0.946 |
| LEP | CCK | ENSMMUP00000007035 | ENSMMUP00000001437 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Cholecystokinin preproprotein. | 0.869 |
| LEP | NPY | ENSMMUP00000007035 | ENSMMUP00000070707 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. | 0.942 |
| LEP | POMC | ENSMMUP00000007035 | ENSMMUP00000075833 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Uncharacterized protein. | 0.961 |
STRING v12.5 is now available!
