Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PLAUPlasminogen activator, urokinase. (430 aa)    
Predicted Functional Partners:
PLAUR
Plasminogen activator, urokinase receptor.
   
 0.999
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
   
 0.998
SERPINE2
Serpin family E member 2; Belongs to the serpin family.
   
 0.993
SERPINB2
Serpin family B member 2; Belongs to the serpin family.
   
 0.989
PLG
Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]
  
 
0.980
SERPINA5
SERPIN domain-containing protein; Belongs to the serpin family.
    
 0.964
SERPING1
Serpin family G member 1; Belongs to the serpin family.
   
 0.930
SERPINA1
SERPIN domain-containing protein; Belongs to the serpin family.
   
 0.929
DMBT1
Uncharacterized protein.
 
  
  0.898
CD5L
CD5 molecule like.
 
  
  0.839
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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