Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)    
Predicted Functional Partners:
SIN3A
SIN3 transcription regulator family member A.
   
 0.999
HDAC2
Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
  
0.999
CHD4
Chromodomain helicase DNA binding protein 4.
   
 0.997
SAP30
Histone deacetylase complex subunit SAP30.
    
 0.996
MTA1
Metastasis associated 1.
   
 0.996
CHD3
Uncharacterized protein.
   
 0.996
GATAD2B
GATA zinc finger domain containing 2B.
   
 0.995
RB1
Retinoblastoma-associated protein.
   
 0.994
RCOR1
REST corepressor 1.
    
 0.994
CTBP1
C-terminal-binding protein 1 isoform 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
 0.992
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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