ATRIP protein (Macaca mulatta) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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Score

ATRIP

ATR-interacting protein isoform 1. (791 aa)

Predicted Functional Partners:

ATR

0.997

FANCM

0.993

FANCI

0.970

FANCA

0.962

WRN

0.950

TOPBP1

0.944

SLF1

0.921

ATM

0.883

RAD17

0.875

RPA1

0.869

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSMMUP00000005561	ENSMMUP00000010409	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.999
ATM	ATRIP	ENSMMUP00000005561	ENSMMUP00000013151	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR-interacting protein isoform 1.	0.883
ATM	FANCA	ENSMMUP00000005561	ENSMMUP00000046621	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group A.	0.506
ATM	FANCI	ENSMMUP00000005561	ENSMMUP00000014608	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group I.	0.737
ATM	FANCM	ENSMMUP00000005561	ENSMMUP00000021700	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group M.	0.746
ATM	RAD17	ENSMMUP00000005561	ENSMMUP00000034561	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RAD17 checkpoint clamp loader component.	0.953
ATM	RPA1	ENSMMUP00000005561	ENSMMUP00000042285	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.781
ATM	SLF1	ENSMMUP00000005561	ENSMMUP00000001861	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMC5-SMC6 complex localization factor 1.	0.808
ATM	TOPBP1	ENSMMUP00000005561	ENSMMUP00000000078	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.931
ATM	WRN	ENSMMUP00000005561	ENSMMUP00000029828	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	WRN RecQ like helicase.	0.985
ATR	ATM	ENSMMUP00000010409	ENSMMUP00000005561	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.999
ATR	ATRIP	ENSMMUP00000010409	ENSMMUP00000013151	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	ATR-interacting protein isoform 1.	0.997
ATR	FANCA	ENSMMUP00000010409	ENSMMUP00000046621	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	FA complementation group A.	0.959
ATR	FANCI	ENSMMUP00000010409	ENSMMUP00000014608	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	FA complementation group I.	0.966
ATR	FANCM	ENSMMUP00000010409	ENSMMUP00000021700	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	FA complementation group M.	0.997
ATR	RAD17	ENSMMUP00000010409	ENSMMUP00000034561	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	RAD17 checkpoint clamp loader component.	0.941
ATR	RPA1	ENSMMUP00000010409	ENSMMUP00000042285	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.916
ATR	SLF1	ENSMMUP00000010409	ENSMMUP00000001861	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	SMC5-SMC6 complex localization factor 1.	0.978
ATR	TOPBP1	ENSMMUP00000010409	ENSMMUP00000000078	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.973
ATR	WRN	ENSMMUP00000010409	ENSMMUP00000029828	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	WRN RecQ like helicase.	0.998