Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HERC3HECT and RLD domain containing E3 ubiquitin protein ligase 3. (1050 aa)    
Predicted Functional Partners:
ISG15
Ubiquitin-like protein ISG15.
   
 0.844
SNX13
Sorting nexin-13.
   
  
 0.674
KLHL42
Kelch domain-containing protein 5.
      
 0.670
ASB7
Ankyrin repeat and SOCS box protein 7 isoform 2.
    
 
 0.665
TRIM5
Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...]
   
 0.647
MYPN
Myopalladin.
      
 0.629
TRIP12
Thyroid hormone receptor interactor 12.
   
 
0.610
NAP1L5
Nucleosome assembly protein 1-like 5; Belongs to the nucleosome assembly protein (NAP) family.
      
 0.607
RAB40C
Ras-related protein Rab-40C isoform a.
      
 0.605
FBXO9
F-box domain-containing protein.
      
 0.602
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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