Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)    
Predicted Functional Partners:
NLRP4
NLR family pyrin domain containing 4.
    
 0.805
NOTCH1
Notch receptor 1.
    
 0.770
TBK1
Serine/threonine-protein kinase TBK1.
    
 0.707
NOTCH4
Notch receptor 4.
     
 0.669
NOTCH2
Neurogenic locus notch homolog protein 2 isoform 1 preproprotein.
     
 0.667
NOTCH3
Notch receptor 3.
     
 0.662
RNF7
RING-box protein 2 isoform 1.
      
 0.635
RNF19A
RBR-type E3 ubiquitin transferase.
      
 0.602
RNF146
E3 ubiquitin-protein ligase RNF146 isoform b.
      
 0.602
ITCH
E3 ubiquitin-protein ligase.
     
 0.601
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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