Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
NF2Merlin isoform 1. (595 aa)    
Predicted Functional Partners:
AMOT
Angiomotin.
    
 0.994
AMOTL1
Angiomotin like 1.
    
 0.992
LATS2
Non-specific serine/threonine protein kinase.
    
 
 0.929
DCAF1
DDB1 and CUL4 associated factor 1.
    
 
 0.928
HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]
    
 
 0.919
LATS1
Large tumor suppressor kinase 1.
    
 
 0.910
FRMD6
FERM domain containing 6.
    
0.892
WWC1
WW and C2 domain containing 1.
    
 0.886
NF1
Neurofibromin 1.
      
 0.879
AMOTL2
Angiomotin like 2.
    
 
 0.838
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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