Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MIPMajor intrinsic protein of lens fiber; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)    
Predicted Functional Partners:
GJA8
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
   
 
 0.856
AQP10
Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
 0.851
LIM2
Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family.
   
 
 0.831
CRYGS
Crystallin gamma S; Belongs to the beta/gamma-crystallin family.
   
 
 0.818
SPRYD4
B30.2/SPRY domain-containing protein.
   
  
 0.817
BFSP2
Beaded filament structural protein 2; Belongs to the intermediate filament family.
   
 
 0.792
GLS2
Glutaminase 2.
   
  
 0.783
GJA3
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
   
 
 0.781
LYZL4
Lysozyme like 4; Belongs to the glycosyl hydrolase 22 family.
   
  
 0.767
AQP11
Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
     
 0.746
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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