CCBE1 protein (Macaca mulatta) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

CCBE1

Collagen and calcium binding EGF domains 1. (406 aa)

Predicted Functional Partners:

VEGFC

0.740

PPL

0.698

ACTG2

0.665

DHRS2

0.654

CHAC1

0.651

MACROD1

0.611

PAMR1

0.592

STX19

0.582

TRAPPC9

0.582

STX11

0.581

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTG2	CCBE1	ENSMMUP00000023266	ENSMMUP00000013639	Actin gamma 2, smooth muscle.	Collagen and calcium binding EGF domains 1.	0.665
CCBE1	ACTG2	ENSMMUP00000013639	ENSMMUP00000023266	Collagen and calcium binding EGF domains 1.	Actin gamma 2, smooth muscle.	0.665
CCBE1	CHAC1	ENSMMUP00000013639	ENSMMUP00000053680	Collagen and calcium binding EGF domains 1.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.651
CCBE1	DHRS2	ENSMMUP00000013639	ENSMMUP00000028771	Collagen and calcium binding EGF domains 1.	Dehydrogenase/reductase 2.	0.654
CCBE1	MACROD1	ENSMMUP00000013639	ENSMMUP00000071612	Collagen and calcium binding EGF domains 1.	Macro domain-containing protein.	0.611
CCBE1	PAMR1	ENSMMUP00000013639	ENSMMUP00000005792	Collagen and calcium binding EGF domains 1.	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	0.592
CCBE1	PPL	ENSMMUP00000013639	ENSMMUP00000032663	Collagen and calcium binding EGF domains 1.	Periplakin.	0.698
CCBE1	STX11	ENSMMUP00000013639	ENSMMUP00000025551	Collagen and calcium binding EGF domains 1.	Syntaxin 11; Belongs to the syntaxin family.	0.581
CCBE1	STX19	ENSMMUP00000013639	ENSMMUP00000043371	Collagen and calcium binding EGF domains 1.	Syntaxin 19; Belongs to the syntaxin family.	0.582
CCBE1	TRAPPC9	ENSMMUP00000013639	ENSMMUP00000071417	Collagen and calcium binding EGF domains 1.	Trafficking protein particle complex 9.	0.582
CCBE1	VEGFC	ENSMMUP00000013639	ENSMMUP00000004996	Collagen and calcium binding EGF domains 1.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.740
CHAC1	CCBE1	ENSMMUP00000053680	ENSMMUP00000013639	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Collagen and calcium binding EGF domains 1.	0.651
CHAC1	DHRS2	ENSMMUP00000053680	ENSMMUP00000028771	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Dehydrogenase/reductase 2.	0.651
CHAC1	PPL	ENSMMUP00000053680	ENSMMUP00000032663	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Periplakin.	0.651
DHRS2	CCBE1	ENSMMUP00000028771	ENSMMUP00000013639	Dehydrogenase/reductase 2.	Collagen and calcium binding EGF domains 1.	0.654
DHRS2	CHAC1	ENSMMUP00000028771	ENSMMUP00000053680	Dehydrogenase/reductase 2.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.651
DHRS2	PPL	ENSMMUP00000028771	ENSMMUP00000032663	Dehydrogenase/reductase 2.	Periplakin.	0.654
MACROD1	CCBE1	ENSMMUP00000071612	ENSMMUP00000013639	Macro domain-containing protein.	Collagen and calcium binding EGF domains 1.	0.611
MACROD1	TRAPPC9	ENSMMUP00000071612	ENSMMUP00000071417	Macro domain-containing protein.	Trafficking protein particle complex 9.	0.587
PAMR1	CCBE1	ENSMMUP00000005792	ENSMMUP00000013639	Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family.	Collagen and calcium binding EGF domains 1.	0.592

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

32

PPI enrichment p-value:

4.87e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009097

Isoleucine biosynthetic process

8 of 19

2.07

4.9

2.25e-12

GO:0009099

Valine biosynthetic process

7 of 14

2.14

4.78

1.81e-11

GO:1901607

Alpha-amino acid biosynthetic process

9 of 97

1.41

2.39

4.47e-10

GO:0019752

Carboxylic acid metabolic process

10 of 313

0.95

1.08

1.47e-07

GO:1901564

Organonitrogen compound metabolic process

10 of 738

0.58

0.48

0.00039

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003984

Acetolactate synthase activity

5 of 9

2.19

3.29

1.81e-07

GO:0030976

Thiamine pyrophosphate binding

5 of 10

2.14

3.25

1.81e-07

GO:0000287

Magnesium ion binding

7 of 54

1.56

2.33

1.81e-07

GO:0019842

Vitamin binding

6 of 67

1.4

1.73

6.00e-06

GO:0050660

Flavin adenine dinucleotide binding

4 of 37

1.48

1.31

0.00072

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005948

Acetolactate synthase complex

4 of 4

2.44

3.19

7.38e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:265

Valine, leucine and isoleucine biosynthesis

8 of 19

2.07

4.98

1.25e-12

CL:268

Valine, leucine and isoleucine biosynthesis

7 of 14

2.14

4.8

1.67e-11

CL:270

Branched-chain amino acid biosynthesis

4 of 8

2.14

2.69

3.66e-06

CL:261

Alpha-amino acid metabolic process, and Glycine, serine and threonine metabolism

9 of 84

1.47

2.64

1.28e-10

CL:77

Mixed, incl. Microbial metabolism in diverse environments, and Valine, leucine and isoleucine biosynthesis

10 of 176

1.2

1.76

7.07e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

8 of 20

2.05

5.11

2.98e-13

map00770

Pantothenate and CoA biosynthesis

7 of 28

1.84

3.74

1.62e-10

map00660

C5-Branched dibasic acid metabolism

5 of 11

2.1

3.61

1.67e-08

map00650

Butanoate metabolism

6 of 32

1.72

2.91

1.73e-08

map01210

2-Oxocarboxylic acid metabolism

7 of 46

1.63

2.87

2.73e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

5 of 9

2.19

3.4

9.96e-08

GOCC:1902494

Catalytic complex

6 of 183

0.96

0.78

0.0015

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

5 of 12

2.06

3.11

2.41e-07

KW-0786

Thiamine pyrophosphate

3 of 6

2.14

1.92

0.00018

KW-0028

Amino-acid biosynthesis

6 of 68

1.39

1.71

6.54e-06

KW-0460

Magnesium

5 of 95

1.17

1.04

0.00064

KW-0479

Metal-binding

6 of 236

0.85

0.65

0.0029

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

5 of 9

2.19

3.26

2.13e-07

PF00205

Thiamine pyrophosphate enzyme, central domain

4 of 4

2.44

3.02

1.65e-06

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

3 of 3

2.44

2.09

0.00012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011766

Thiamine pyrophosphate enzyme, TPP-binding

5 of 9

2.19

3.08

5.48e-07

IPR045229

Thiamine pyrophosphate enzyme

4 of 4

2.44

2.91

2.82e-06

IPR012000

Thiamine pyrophosphate enzyme, central domain

4 of 4

2.44

2.91

2.82e-06

IPR029061

Thiamin diphosphate-binding fold

5 of 15

1.97

2.64

2.10e-06

IPR029035

DHS-like NAD/FAD-binding domain superfamily

4 of 10

2.05

2.27

2.39e-05

(more ...)

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