| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRH | CRHBP | ENSMMUP00000028431 | ENSMMUP00000028130 | Corticotropin releasing hormone. | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | 0.946 |
| CRH | CRHR1 | ENSMMUP00000028431 | ENSMMUP00000055825 | Corticotropin releasing hormone. | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | 0.999 |
| CRH | CRHR2 | ENSMMUP00000028431 | ENSMMUP00000015437 | Corticotropin releasing hormone. | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | 0.999 |
| CRH | GHRL | ENSMMUP00000028431 | ENSMMUP00000062710 | Corticotropin releasing hormone. | Ghrelin and obestatin prepropeptide. | 0.754 |
| CRH | UCN | ENSMMUP00000028431 | ENSMMUP00000059719 | Corticotropin releasing hormone. | Urocortin. | 0.981 |
| CRH | UCN2 | ENSMMUP00000028431 | ENSMMUP00000076773 | Corticotropin releasing hormone. | Urocortin 2. | 0.973 |
| CRH | UCN3 | ENSMMUP00000028431 | ENSMMUP00000070587 | Corticotropin releasing hormone. | Urocortin 3. | 0.967 |
| CRHBP | CRH | ENSMMUP00000028130 | ENSMMUP00000028431 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Corticotropin releasing hormone. | 0.946 |
| CRHBP | CRHR1 | ENSMMUP00000028130 | ENSMMUP00000055825 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | 0.895 |
| CRHBP | CRHR2 | ENSMMUP00000028130 | ENSMMUP00000015437 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | 0.805 |
| CRHBP | UCN | ENSMMUP00000028130 | ENSMMUP00000059719 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Urocortin. | 0.931 |
| CRHBP | UCN2 | ENSMMUP00000028130 | ENSMMUP00000076773 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Urocortin 2. | 0.530 |
| CRHBP | UCN3 | ENSMMUP00000028130 | ENSMMUP00000070587 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Urocortin 3. | 0.503 |
| CRHR1 | CRH | ENSMMUP00000055825 | ENSMMUP00000028431 | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | Corticotropin releasing hormone. | 0.999 |
| CRHR1 | CRHBP | ENSMMUP00000055825 | ENSMMUP00000028130 | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | 0.895 |
| CRHR1 | CRHR2 | ENSMMUP00000055825 | ENSMMUP00000015437 | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | 0.953 |
| CRHR1 | GHRL | ENSMMUP00000055825 | ENSMMUP00000062710 | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | Ghrelin and obestatin prepropeptide. | 0.565 |
| CRHR1 | UCN | ENSMMUP00000055825 | ENSMMUP00000059719 | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | Urocortin. | 0.998 |
| CRHR1 | UCN2 | ENSMMUP00000055825 | ENSMMUP00000076773 | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | Urocortin 2. | 0.991 |
| CRHR1 | UCN3 | ENSMMUP00000055825 | ENSMMUP00000070587 | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] | Urocortin 3. | 0.990 |
