Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
CPS1Carbamoyl-phosphate synthase 1. (1529 aa)    
Predicted Functional Partners:
OTC
Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
 
 
 0.992
ASS1
Argininosuccinate synthase.
 
 
 0.965
LOC702037
Uncharacterized protein.
 
 
 0.964
GLUL
Glutamine synthetase.
  
 0.959
GLUD1
Glutamate dehydrogenase 1, mitochondrial; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.959
GLS2
Glutaminase 2.
   
 
 0.943
SIRT5
NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...]
  
 0.911
ASL
RPOL4c domain-containing protein.
  
 
 0.911
GLS
Glutaminase kidney isoform, mitochondrial isoform 1.
     
 0.909
CAD
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.
  
  
 
0.903
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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