STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNP2Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (141 aa)    
Predicted Functional Partners:
MSH4
mutS homolog 4
   
  
 0.912
PRM2
Protamine-2
   
  
 0.860
PRM3
Protamine 3
   
  
 0.812
NR0B1
Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity); Belongs to the nuclear hormone receptor family. NR0 subfamily
   
  
 0.762
RHOXF1
Paired-like homeobox protein PEPP-1; Uncharacterized protein
      
 0.727
TCEB1
RNA polymerase II transcription factor SIII subunit C; Transcription elongation factor B polypeptide 1 isoform a; Uncharacterized protein ; Belongs to the SKP1 family
    
 
 0.684
KPNA3
Importin subunit alpha; Functions in nuclear protein import
      
 0.683
SPO11
Ribonucleic acid export 1; SPO11 meiotic protein covalently bound to DSB
      
 0.651
NMT1
Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins
      
 0.647
SPATA33
Spermatogenesis associated 33
   
  
 0.647
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Macaca mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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