Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADH4Alcohol dehydrogenase 4 (class II), pi polypeptide. (398 aa)    
Predicted Functional Partners:
ALDH3A1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 0.977
ALDH1A1
Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.
  
 0.970
ALDH3B1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 0.969
ESD
S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.
 0.956
ALDH3B2
Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family.
  
 0.946
ALDH1A3
Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family.
  
 0.945
CYP2E1
Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
  
 
 0.941
RETSAT
Retinol saturase.
  
 
 0.937
ALDH1A2
Retinal dehydrogenase 2 isoform 1; Belongs to the aldehyde dehydrogenase family.
  
 0.935
LOC114669719
Uncharacterized protein.
  
 
 0.918
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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