Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
TYRTyrosinase. (530 aa)    
Predicted Functional Partners:
TRPM1
Transient receptor potential cation channel subfamily M member 1.
   
 
 0.978
MLANA
Melanoma antigen recognized by T-cells 1.
   
  
 0.970
TYRP1
Tyrosinase related protein 1.
  
 
0.946
OCA2
OCA2 melanosomal transmembrane protein.
   
  
 0.943
TH
Tyrosine hydroxylase.
     
 0.929
DDC
Aromatic-L-amino-acid decarboxylase.
    
 0.926
TAT
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
     
 0.920
GOT2
Aspartate aminotransferase.
    
 0.916
MITF
Microphthalmia-associated transcription factor isoform 1.
   
 0.914
PRKCB
Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
    
 0.913
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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