NR6A1 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

NR6A1

Nuclear receptor subfamily 6 group A member 1. (480 aa)

Predicted Functional Partners:

NCOR1

0.873

NCOR2

0.738

UIMC1

0.715

MUL1

0.707

SYCP3

0.652

FAM9C

0.638

NKX1-2

0.607

MED1

0.603

ATP6V0A2

0.593

TDGF1

0.591

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6V0A2	NR6A1	ENSMMUP00000008617	ENSMMUP00000014647	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	Nuclear receptor subfamily 6 group A member 1.	0.593
FAM9C	NR6A1	ENSMMUP00000041256	ENSMMUP00000014647	Family with sequence similarity 9 member C.	Nuclear receptor subfamily 6 group A member 1.	0.638
MED1	NCOR1	ENSMMUP00000062442	ENSMMUP00000003403	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor corepressor 1.	0.698
MED1	NCOR2	ENSMMUP00000062442	ENSMMUP00000038418	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor corepressor 2.	0.680
MED1	NR6A1	ENSMMUP00000062442	ENSMMUP00000014647	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor subfamily 6 group A member 1.	0.603
MUL1	NR6A1	ENSMMUP00000069716	ENSMMUP00000014647	Mitochondrial ubiquitin ligase activator of NFKB 1.	Nuclear receptor subfamily 6 group A member 1.	0.707
NCOR1	MED1	ENSMMUP00000003403	ENSMMUP00000062442	Nuclear receptor corepressor 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.698
NCOR1	NCOR2	ENSMMUP00000003403	ENSMMUP00000038418	Nuclear receptor corepressor 1.	Nuclear receptor corepressor 2.	0.964
NCOR1	NR6A1	ENSMMUP00000003403	ENSMMUP00000014647	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 6 group A member 1.	0.873
NCOR2	MED1	ENSMMUP00000038418	ENSMMUP00000062442	Nuclear receptor corepressor 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.680
NCOR2	NCOR1	ENSMMUP00000038418	ENSMMUP00000003403	Nuclear receptor corepressor 2.	Nuclear receptor corepressor 1.	0.964
NCOR2	NR6A1	ENSMMUP00000038418	ENSMMUP00000014647	Nuclear receptor corepressor 2.	Nuclear receptor subfamily 6 group A member 1.	0.738
NKX1-2	NR6A1	ENSMMUP00000076560	ENSMMUP00000014647	NK1 homeobox 2.	Nuclear receptor subfamily 6 group A member 1.	0.607
NKX1-2	TDGF1	ENSMMUP00000076560	ENSMMUP00000077275	NK1 homeobox 2.	Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.	0.564
NR6A1	ATP6V0A2	ENSMMUP00000014647	ENSMMUP00000008617	Nuclear receptor subfamily 6 group A member 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.593
NR6A1	FAM9C	ENSMMUP00000014647	ENSMMUP00000041256	Nuclear receptor subfamily 6 group A member 1.	Family with sequence similarity 9 member C.	0.638
NR6A1	MED1	ENSMMUP00000014647	ENSMMUP00000062442	Nuclear receptor subfamily 6 group A member 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.603
NR6A1	MUL1	ENSMMUP00000014647	ENSMMUP00000069716	Nuclear receptor subfamily 6 group A member 1.	Mitochondrial ubiquitin ligase activator of NFKB 1.	0.707
NR6A1	NCOR1	ENSMMUP00000014647	ENSMMUP00000003403	Nuclear receptor subfamily 6 group A member 1.	Nuclear receptor corepressor 1.	0.873
NR6A1	NCOR2	ENSMMUP00000014647	ENSMMUP00000038418	Nuclear receptor subfamily 6 group A member 1.	Nuclear receptor corepressor 2.	0.738