Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
PBX1Pre-B-cell leukemia transcription factor 1 isoform 1. (430 aa)    
Predicted Functional Partners:
PKNOX1
PBX/knotted 1 homeobox 1.
   
 0.979
MEIS1
Meis homeobox 1.
   
0.959
MEIS2
Meis homeobox 2.
   
0.957
HOXB1
Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity); Belongs to the Antp homeobox family. Labial subfamily.
    
 0.933
PBX2
Pre-B-cell leukemia transcription factor 2.
   
 
 0.907
MAB21L1
Uncharacterized protein.
   
 
 0.907
PBX3
Pre-B-cell leukemia transcription factor 3 isoform 1.
   
   0.906
SIRT1
Sirtuin 1.
     
 0.901
PRKACG
cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
     
  0.900
PRKACA
Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.
     
  0.900
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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