Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (572 aa)    
Predicted Functional Partners:
CAD
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.
   
  
 0.796
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 0.777
PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial.
      
 0.771
SLC10A1
Solute carrier family 10 member a1.
      
 0.767
NOTUM
Notum, palmitoleoyl-protein carboxylesterase.
    
 0.763
SDC2
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
   
 0.737
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 0.670
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 0.670
ALDH1A1
Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.
   
 
 0.655
APOE
Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]
     
 0.652
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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