STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)    
Predicted Functional Partners:
MMP3
Matrix metallopeptidase 3.
   
 0.966
MMP1
Matrix metallopeptidase 1.
   
 0.965
MMP9
Uncharacterized protein.
   
 0.964
MMP14
Matrix metalloproteinase-14 preproprotein.
   
 0.961
MMP10
Matrix metallopeptidase 10.
   
 0.928
MMP7
Matrix metallopeptidase 7.
   
 0.868
MMP2
72 kDa type IV collagenase isoform a preproprotein.
   
 0.855
CD63
Tetraspanin.
   
 
 0.828
ELSPBP1
Epididymis-specific type IV collagenase-like protein.
   
 0.807
MMP8
Matrix metallopeptidase 8.
   
 0.794
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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