HSD3B1 protein (Macaca mulatta) - STRING interaction network

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HSD3B1

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; Belongs to the 3-beta-HSD family. (373 aa)

Predicted Functional Partners:

CYP17A1

0.988

LOC708065

0.986

CYP19A1

0.983

HSD17B3

0.982

CYP21A2

0.963

CYP11B1

0.960

SULT2B1

0.950

CYP7B1

0.948

SRD5A1

0.947

CYP7A1

0.946

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP11B1	CYP17A1	ENSMMUP00000031896	ENSMMUP00000061406	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.961
CYP11B1	CYP19A1	ENSMMUP00000031896	ENSMMUP00000053305	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 19A1; Belongs to the cytochrome P450 family.	0.947
CYP11B1	CYP21A2	ENSMMUP00000031896	ENSMMUP00000001019	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.964
CYP11B1	CYP7B1	ENSMMUP00000031896	ENSMMUP00000005888	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.484
CYP11B1	HSD17B3	ENSMMUP00000031896	ENSMMUP00000038724	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.947
CYP11B1	HSD3B1	ENSMMUP00000031896	ENSMMUP00000015345	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; Belongs to the 3-beta-HSD family.	0.960
CYP11B1	SRD5A1	ENSMMUP00000031896	ENSMMUP00000017322	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.942
CYP17A1	CYP11B1	ENSMMUP00000061406	ENSMMUP00000031896	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	0.961
CYP17A1	CYP19A1	ENSMMUP00000061406	ENSMMUP00000053305	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cytochrome P450 19A1; Belongs to the cytochrome P450 family.	0.961
CYP17A1	CYP21A2	ENSMMUP00000061406	ENSMMUP00000001019	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.937
CYP17A1	CYP7A1	ENSMMUP00000061406	ENSMMUP00000008613	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.961
CYP17A1	CYP7B1	ENSMMUP00000061406	ENSMMUP00000005888	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.927
CYP17A1	HSD17B3	ENSMMUP00000061406	ENSMMUP00000038724	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.980
CYP17A1	HSD3B1	ENSMMUP00000061406	ENSMMUP00000015345	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; Belongs to the 3-beta-HSD family.	0.988
CYP17A1	LOC708065	ENSMMUP00000061406	ENSMMUP00000033428	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.964
CYP17A1	SRD5A1	ENSMMUP00000061406	ENSMMUP00000017322	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.977
CYP17A1	SULT2B1	ENSMMUP00000061406	ENSMMUP00000029166	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Sulfotransferase; Belongs to the sulfotransferase 1 family.	0.936
CYP19A1	CYP11B1	ENSMMUP00000053305	ENSMMUP00000031896	Cytochrome P450 19A1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 11 subfamily B member 1; Belongs to the cytochrome P450 family.	0.947
CYP19A1	CYP17A1	ENSMMUP00000053305	ENSMMUP00000061406	Cytochrome P450 19A1; Belongs to the cytochrome P450 family.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.961
CYP19A1	CYP21A2	ENSMMUP00000053305	ENSMMUP00000001019	Cytochrome P450 19A1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.526

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