Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1442 aa)    
Predicted Functional Partners:
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.980
AKT2
AKT serine/threonine kinase 2.
    
 0.975
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1.
  
 
0.975
AKT1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.973
USP46
USP domain-containing protein; Belongs to the peptidase C19 family.
    
 
 0.924
WDR20
WD_REPEATS_REGION domain-containing protein.
    
 
 0.919
USP12
Ubiquitin carboxyl-terminal hydrolase 12; Belongs to the peptidase C19 family.
    
 
 0.806
WDR48
WD repeat domain 48.
   
 
 0.776
SNX27
Sorting nexin 27.
    
 
 0.771
USP1
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
    
 
 0.758
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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