| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACP1 | OCA2 | ENSMMUP00000022497 | ENSMMUP00000015778 | LMWPc domain-containing protein. | OCA2 melanosomal transmembrane protein. | 0.703 |
| ASIP | MC1R | ENSMMUP00000077604 | ENSMMUP00000032257 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). | 0.981 |
| ASIP | OCA2 | ENSMMUP00000077604 | ENSMMUP00000015778 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | OCA2 melanosomal transmembrane protein. | 0.714 |
| ASIP | SLC24A4 | ENSMMUP00000077604 | ENSMMUP00000018349 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.577 |
| ASIP | SLC24A5 | ENSMMUP00000077604 | ENSMMUP00000024781 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.746 |
| ASIP | SLC45A2 | ENSMMUP00000077604 | ENSMMUP00000034889 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Solute carrier family 45 member 2. | 0.685 |
| ASIP | TYR | ENSMMUP00000077604 | ENSMMUP00000014548 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Tyrosinase. | 0.743 |
| ASIP | TYRP1 | ENSMMUP00000077604 | ENSMMUP00000071668 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Tyrosinase related protein 1. | 0.779 |
| GPR143 | MC1R | ENSMMUP00000041250 | ENSMMUP00000032257 | G protein-coupled receptor 143. | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). | 0.403 |
| GPR143 | OCA2 | ENSMMUP00000041250 | ENSMMUP00000015778 | G protein-coupled receptor 143. | OCA2 melanosomal transmembrane protein. | 0.837 |
| GPR143 | SLC24A5 | ENSMMUP00000041250 | ENSMMUP00000024781 | G protein-coupled receptor 143. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.791 |
| GPR143 | SLC45A2 | ENSMMUP00000041250 | ENSMMUP00000034889 | G protein-coupled receptor 143. | Solute carrier family 45 member 2. | 0.847 |
| GPR143 | TYR | ENSMMUP00000041250 | ENSMMUP00000014548 | G protein-coupled receptor 143. | Tyrosinase. | 0.880 |
| GPR143 | TYRP1 | ENSMMUP00000041250 | ENSMMUP00000071668 | G protein-coupled receptor 143. | Tyrosinase related protein 1. | 0.884 |
| KITLG | OCA2 | ENSMMUP00000078855 | ENSMMUP00000015778 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | OCA2 melanosomal transmembrane protein. | 0.751 |
| KITLG | SLC24A4 | ENSMMUP00000078855 | ENSMMUP00000018349 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.523 |
| KITLG | SLC24A5 | ENSMMUP00000078855 | ENSMMUP00000024781 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.498 |
| KITLG | SLC45A2 | ENSMMUP00000078855 | ENSMMUP00000034889 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Solute carrier family 45 member 2. | 0.603 |
| KITLG | TYR | ENSMMUP00000078855 | ENSMMUP00000014548 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Tyrosinase. | 0.541 |
| KITLG | TYRP1 | ENSMMUP00000078855 | ENSMMUP00000071668 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. | Tyrosinase related protein 1. | 0.553 |
